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Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.

 

This paper uses accounting concepts—particularly the concept of Return on Investment (ROI)—to reveal the quantitative value of scientific research pertaining to a major US cyberinfrastructure project (XSEDE—the eXtreme Science and Engineering Discovery Environment). XSEDE provides operational and support services for advanced information technology systems, cloud systems, and supercomputers supporting non-classified US research, with an average budget for XSEDE of US$20M+ per year over the period studied (2014–2021). To assess the financial effectiveness of these services, we calculated a proxy for ROI, and converted quantitative measures of XSEDE service delivery into financial values using costs for service from the US marketplace. We calculated two estimates of ROI: a Conservative Estimate, functioning as a lower bound and using publicly available data for a lower valuation of XSEDE services; and a Best Available Estimate, functioning as a more accurate estimate, but using some unpublished valuation data. Using the largest dataset assembled for analysis of ROI for a cyberinfrastructure project, we found a Conservative Estimate of ROI of 1.87, and a Best Available Estimate of ROI of 3.24. Through accounting methods, we show that XSEDE services offer excellent value to the US government, that the services offered uniquely by XSEDE (that is, not otherwise available for purchase) were the most valuable to the facilitation of US research activities, and that accounting-based concepts hold great value for understanding the mechanisms of scientific research generally.

 

Jetstream2 will be a category I production cloud resource that is part of the National Science Foundation’s Innovative HPC Program. The project’s aim is to accelerate science and engineering by providing “on-demand” programmable infrastructure built around a core system at Indiana University and four regional sites. Jetstream2 is an evolution of the Jetstream platform, which functions primarily as an Infrastructure-as-a-Service cloud. The lessons learned in cloud architecture, distributed storage, and container orchestration have inspired changes in both hardware and software for Jetstream2. These lessons have wide implications as institutions converge HPC and cloud technology while building on prior work when deploying their own cloud environments. Jetstream2’s next-generation hardware, robust open-source software, and enhanced virtualization will provide a significant platform to further cloud adoption within the US research and education communities.